Think of humanity’s worst plagues, and the Black Death, the Spanish flu, and COVID-19 all come to mind. Millions have died in those deadly pandemics, but their toll pales in comparison with that of tuberculosis (TB), which has killed more than 1 billion people over the past 2000 years—and still kills 1.5 million people worldwide every year. But how and when TB got to be so deadly has long been a mystery.

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