If you use your mouse all day for work, you may find the straight, ambidextrous design of most mice uncomfortable by the end of a long workday. There are many mice these days that are designed with a slanted shape or a thumb rest to help with ergonomics and create a more comfortable user experience. While we don’t test for the long-term effects of ergonomic mice, the following mice all have an at least somewhat slanted and comfortable design and have easy-to-reach buttons.