Put human stem cells in a lab dish with the right nutrients, and they’ll do their best to form a little brain. They’ll fail, but you’ll get an organoid: a semiorganized clump of cells. Organoids have become a powerful tool for studying brain development and disease, but researchers assumed these microscopic blobs only mirror a brain’s prenatal development—its earliest and simplest stages. A study today reveals that with enough time, organoid cells can take on some of the genetic signatures that brain cells display after birth, potentially expanding the range of disorders and developmental stages they can recreate.