Antibody-producing yeast vanquishes deadly gut infection in mice

When people take antibiotics for one infection, another can swoop in to take its place: the bacterium Clostridioides difficile, which causes severe, recurring colon infections that kill nearly 30,000 people annually in the United States, most over the age of 65. Now, researchers have a new idea for battling C. diff: They have modified yeast to produce and deliver antibodies that defang the bacterium’s two toxins and spur recovery in infected mice.

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